2,3-DIHYDRO-1,2-BENZISOTHIAZOLE-3-ONE-1,1-DIOXIDESODIUM SALT DIHYDRATE
Saccharin sodium salt dihydrate
CAS: 6155-57-3
Molecular Formula: C7H8NNaO4S
2,3-DIHYDRO-1,2-BENZISOTHIAZOLE-3-ONE-1,1-DIOXIDESODIUM SALT DIHYDRATE - Names and Identifiers
| Name | Saccharin sodium salt dihydrate |
| Synonyms | SOLUBLE SACCHARIN Saccharin sodium dihydrate Sodium saccharine dihydrate O-BENZOIC SULFIMIDE SODIUM SALT Saccharin sodium salt dihydrate O-SULFOBENZIMIDE SODIUM SALT DIHYDRATE O-BENZOIC SULFIMIDE SODIUM SALT DIHYDRATE O-BENZOIC ACID SULFIMIDE SODIUM SALT DIHYDRATE 2-SULFOBENZOIC AND IMIDE SODIUM SALT DIHYDRATE 1,1-DIOXIDE-1,2-BENZISOTHIAZOLE-3(2H)-ONE SODIUM SALT, DIHYDRATE 2,3-DIHYDRO-1,2-BENZISOTHIAZOLE-3-ONE-1,1-DIOXIDESODIUM SALT DIHYDRATE |
| CAS | 6155-57-3 |
| EINECS | 612-173-5 |
| InChI | InChI=1/C7H5NO3S.Na.2H2O/c9-7-5-3-1-2-4-6(5)12(10,11)8-7;;;/h1-4H,(H,8,9);;2*1H2/q;+1;;/p-1 |
| InChIKey | BCWVKFPXENUOQA-UHFFFAOYSA-N |
2,3-DIHYDRO-1,2-BENZISOTHIAZOLE-3-ONE-1,1-DIOXIDESODIUM SALT DIHYDRATE - Physico-chemical Properties
| Molecular Formula | C7H8NNaO4S |
| Molar Mass | 225.19 |
| Melting Point | > 300℃ |
| Boling Point | 438.9°C at 760 mmHg |
| Flash Point | >200°C |
| Water Solubility | Soluble in water. Slightly soluble in alcohol |
| Solubility | 1000g/l |
| Vapor Presure | 1.77E-08mmHg at 25°C |
| Appearance | powder to crystaline |
| Color | White to Almost white |
| Merck | 14,8311 |
| PH | 6.0-7.5 (100g/l, H2O, 20℃) |
| Storage Condition | 2-8°C |
| Physical and Chemical Properties | White rhomboid crystal or crystalline powder, odorless, micro-aromatic gas, a strong sweet taste, after a slightly bitter taste, sweetness of sucrose 300-500 times. Melting point 226-231 °c. Soluble in water (99.8g,20 °c; 186.8g,50 °c; 328.3g,95 °c), soluble in ethanol (1g/50ml). In the air slowly weathering, about half of the loss of crystal water and become white powder. Mice were intraperitoneally injected with LD5017500mg/kg, rats oral MNL500mg/kg,ADI0-5mg/kg(FAO/WHO,1994). |
2,3-DIHYDRO-1,2-BENZISOTHIAZOLE-3-ONE-1,1-DIOXIDESODIUM SALT DIHYDRATE - Risk and Safety
| Risk Codes | 22 - Harmful if swallowed |
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 2 |
| RTECS | DE4375000 |
| TSCA | Yes |
| HS Code | 29350090 |
| Toxicity | LD50 orally in Rabbit: 14200 mg/kg |
2,3-DIHYDRO-1,2-BENZISOTHIAZOLE-3-ONE-1,1-DIOXIDESODIUM SALT DIHYDRATE - Nature
Open Data Verified Data
White rhomboid crystal or crystalline powder, odorless, micro-aromatic gas, a strong sweet taste, after a slightly bitter taste, sweetness of sucrose 300~500 times. Soluble in water, soluble in ethanol (lg/50mL). In the air slowly weathering, lose part of the water of crystallization and become white powder.
Last Update：2024-01-02 23:10:35
2,3-DIHYDRO-1,2-BENZISOTHIAZOLE-3-ONE-1,1-DIOXIDESODIUM SALT DIHYDRATE - Preparation Method
Open Data Verified Data
from phthalic anhydride by amination, degradation, esterification, diazotization, replacement, chlorination, cyclization, acid precipitation, neutralization and so on.
Last Update：2022-01-01 10:10:04
2,3-DIHYDRO-1,2-BENZISOTHIAZOLE-3-ONE-1,1-DIOXIDESODIUM SALT DIHYDRATE - Use
Open Data Verified Data
used as a sweetener. At the same concentration, the sweetness was 500 times that of sucrose. The combination of saccharin sodium and acid has a quick sweet taste and is suitable for use as a sweetener for cool drinks. The combination with other sweeteners can bring out the sweet taste close to sucrose. For plum and orange peel, the maximum use of 5Og/kg; In the seeds of the maximum use of 1. 2g/kg; In beverages, wine, ice creams, ice cream, popsicles, pickles, compound spices, preserves, cakes, biscuits and bread in the maximum use of 0. 15g/kg, concentrated juice according to the concentration of 80%. Saccharin sodium does not produce calories, suitable for use as a sweetener for patients with diabetes, heart disease, obesity, can also be used for low calorie food production.
Last Update：2022-01-01 10:10:05
2,3-DIHYDRO-1,2-BENZISOTHIAZOLE-3-ONE-1,1-DIOXIDESODIUM SALT DIHYDRATE - Reference Information
| properties | saccharin sodium, also known as soluble saccharin, is the sodium salt of saccharin, with two crystal water, colorless crystal or slightly white crystalline powder, generally contains two crystal water, easy to lose the water of crystallization into anhydrous saccharin, white powder, odorless or micro aroma, sweet and bitter. The sweetness of saccharin sodium is about 500 times that of sucrose. Saccharin sodium heat-resistant and alkali-resistant weak, acidic conditions heating sweet gradually disappeared, more than 0.026% of the solution is bitter. |
| Application | sweetener, saccharin sodium is an organic chemical synthetic product, is a food additive rather than food, there is no nutritional value to the human body except for the feeling of sweet in the sense of taste. On the contrary, when eating more saccharin, will affect the normal secretion of gastrointestinal digestive enzymes, reduce the absorption capacity of the small intestine, so that loss of appetite. Widely used in the following industries: 1, food: General cold drinks, beverages, jelly, cold fruit, protein sugar, etc. 2, feed additives: pig feed, sweet, etc. 3, daily chemical industry: toothpaste, mouth water, eye drops, etc. 4, electroplating industry: Electroplating brightener, which is a large amount of electroplating industry, the current total exports accounted for the majority of China's output. |
| Use | sodium saccharin is a commonly used synthetic sweetener. In the human body is not absorbed, does not produce heat. Can be used for plum and tangerine peel, the maximum use of 5.0g/kg, the maximum use of 1.2g/kg in melon seeds; In beverages, wine, ice cream, ice cream, popsicles, pickles, compound seasoning, max 0.15g/kg in preserves, cakes, biscuits and bread; Juice concentrate is added at 80% of the concentration. |
| production method | by amination, degradation, esterification, diazotization, replacement, chlorination, cyclization, acid precipitation, neutralization and other steps. (1) preparation of methyl anthranilate. Add phthalic anhydride and ammonia water at 0 ℃ to the reaction kettle in sequence, slowly drop sodium hydroxide solution after raising the temperature to 50 ℃, aminate under the condition of keeping the temperature below 70 ℃ and PH8.5-8.9, and then adjust the PH = 12-13, at 65-70 C insulation 0.5h degradation, after the completion of the heat preservation ammonia 3.5h. Cool to -10 °c, add -10 °c methanol and sodium hypochlorite solution (not excessive), esterification at 0 °c for 45min, then gradually warm to 30 °c, with the starch potassium iodide test paper test showed colorless reaction. Then, an appropriate amount of 20% sodium bisulfite solution is added, after the liquid solution is diluted, the temperature is raised to above 50 ° C., and then hot water of 80 ° C. Is added, stirred and dissolved, left standing and filtered, and the oil layer is separated to obtain methyl anthranilate. (2) preparation of methyl benzoate with O-sulfonyl chloride. First, the mixed acid is placed in a diazo pot, and a mixed solution of methyl anthranilate and sodium nitrite solution is added dropwise at about 10 ° C. The diazotization temperature is kept below 25 ° C. The starch potassium iodide solution is light green at the end of the reaction. After completion of diazotization, the temperature is lowered to 10 ℃, copper sulfate is added, after dissolution, SO2 is introduced for replacement, and methyl benzoate O-sulfinic acid is precipitated at this time, After about 1H, the end point of the reaction should be colorless with H acid test paper. Then toluene was added, chlorine gas was chlorinated at 30-35 ° C., and the end point of the test was dark green in 2% benzidine ethanol solution. The mixture was allowed to stand and layered, and the organic layer was a toluene solution of O-sulfonyl chloride methyl benzoate. (3) preparation of insoluble saccharin. Water and O-sulfonyl chloride methyl benzoate toluene solution were added to the reaction pot in turn, ammonia water was added at 10 ℃, and the reaction was stirred for 15min (the temperature could reach 70 ℃, pH above 9), the end point of cyclization was not immediately yellow when tested with 2% benzidine pyridine solution. After standing, the lower ammonium salt solution was taken, toluene and 30% hydrochloric acid were added, and the PH was lowered to below 1. After acid analysis, the temperature was lowered to 20 ℃, and the toluene layer was washed with water to remove ammonium chloride to obtain saccharin toluene solution. (4) preparation of soluble saccharin. The insoluble saccharin toluene solution is heated to 40 ℃, sodium bicarbonate and water are added to adjust PH to 3.8-4, the water layer is taken after standing, activated carbon is added to decolorize and filter, and the PH of the filtrate is adjusted to 7, add activated carbon to decolorize once. The filtrate was concentrated under reduced pressure at 70-75 °c and filtered while hot, maintaining a PH of 7. The filtrate was cooled, crystallized, filtered and dried to obtain sodium saccharin. |
Last Update：2024-04-09 20:44:15
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Product Name: Saccharin Sodium Dihydrate Visit Supplier Webpage Request for quotationCAS: 6155-57-3
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Email: 3008007409@qq.com
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Multiple Specifications
Product Name: Saccharin Sodium Dihydrate Visit Supplier Webpage Request for quotationCAS: 6155-57-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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